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Updated: Jun 20, 2026

Synthesis and Assay of Vibrio Quorum Sensing Inhibitors
Published on: May 31, 2024
A naturally occurring brominated furanone covalently modifies and inactivates LuxS
Tianzhu Zang1, Bobby W K Lee, Lisa M Cannon
1The Barnett Institute and the Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
Abstract:
Halogenated furanones, a group of natural products initially isolated from marine red algae, are known to inhibit bacterial biofilm formation, swarming, and quorum sensing. However, their molecular targets and the precise mode of action remain elusive. Herein, we show that a naturally occurring brominated furanone covalently modifies and inactivates LuxS (S-ribosylhomocysteine lyase, EC 4.4.1.21), the enzyme which produces autoinducer-2 (AI-2).
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