Related Experiment Video
Updated: Jun 20, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Natural history and predictors for progression of mild childhood obstructive sleep apnoea
1Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong. albertmli@cuhk.edu.hk
Insights
Mild childhood obstructive sleep apnoea (OSA) often persists and can worsen, particularly in boys with large tonsils and increased waist circumference. Early monitoring and weight management are crucial for affected children.
Area of Science:
- Pediatric Pulmonology
- Sleep Medicine
- Epidemiology
Background:
- Childhood obstructive sleep apnoea (OSA) is a prevalent condition with potential long-term health implications.
- Understanding the natural history and progression factors of mild OSA in children is essential for effective management.
Purpose of the Study:
- To investigate the natural course of mild obstructive sleep apnoea in children over a two-year period.
- To identify clinical and demographic factors associated with the progression of mild childhood OSA.
Main Methods:
- Recruited 56 Chinese children aged 6-13 years with mild OSA (apnoea-hypopnoea index 1-5) from an epidemiological study.
- Conducted a follow-up assessment after 2 years to evaluate changes in OSA severity.
- Utilized multivariate regression analysis to identify predictors of OSA worsening.
Main Results:
- Of 45 children completing follow-up, 29% showed worsened OSA.
- Worsening OSA was associated with greater increases in waist circumference, large tonsils, and habitual snoring.
- Factors predicting worsening included age, male gender, baseline large tonsils, and changes in waist circumference.
Conclusions:
- Mild childhood OSA frequently does not resolve spontaneously and may progress.
- Children with tonsillar hypertrophy, especially boys, require close monitoring for OSA progression.
- Weight control is a key recommendation for managing childhood OSA.
Aims:
The natural history of mild childhood obstructive sleep apnoea (OSA) was examined and factors associated with disease progression were identified.
Methods:
Subjects were recruited from an epidemiological study which examined the prevalence of OSA in Chinese children aged 6-13 years. The first 56 consecutive children identified with mild OSA (apnoea-hypopnoea index 1-5) were invited for a repeat assessment 2 years after the diagnosis.
Results:
45 children participated in the follow-up study, in 13 of whom (29%) the OSA was found to have worsened. Compared with those in whom OSA had not worsened, the worsened OSA group had a greater increase in waist circumference, a higher prevalence of large tonsils (occupying > or =50% of the airway) at both baseline and follow-up, and a higher prevalence of habitual snoring at both baseline and follow-up. The presence of large tonsils had a positive predictive value of 53% and a negative predictive value of 83% for worsening OSA over a 2-year period. Multivariate linear regression analysis showed that the change in obstructive apnoea-hypopnoea index was associated with age at baseline (beta (SE) = -0.92 (0.34), p = 0.009), gender (male = 1; female = 0) (beta (SE) = 4.69 (1.29), p<0.001), presence of large tonsils at baseline (beta (SE) = 4.36 (1.24), p = 0.001), change in waist circumference (beta (SE) = 0.30 (0.09), p = 0.002) and persistently large tonsils (beta (SE) = 5.69 (1.36), p<0.001) over the 2-year period.
Conclusions:
Mild OSA in the majority of children does not resolve spontaneously. Subjects with tonsillar hypertrophy, especially boys, should be closely monitored to allow early detection of worsening OSA. Weight control should be stressed in the management of childhood OSA.
Related Concept Videos
Sleep Apnea
The condition is more prevalent among...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic Obstructive Pulmonary Disease I: Introduction
Other Pulmonary Disorders
Assessment of Airway, Skin Color, and Use of Accessory Muscles
Introduction
The initial evaluation of a patient's respiratory system...
Chronic Obstructive Pulmonary Disease-I: Introduction