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Published on: August 8, 2022
A cross-sectional study of familial clustering in hyperhomocysteinemia
Satoko Mitani1, Kotaro Ozasa, Masako Shigeta
1Kyoto Prefectural University of Medicine, Kyoto, Japan. mitani@koto.kpu-m.ac.jp
Background:
Hyperhomocysteinemia is correlated with diseases and lifestyle habits. However, there is no epidemiological evidence concerning the distribution and prevalence of hyperhomocysteinemia in a local community.
Objective:
The purpose of this study was to clarify the distribution and prevalence of hyperhomocysteinemia and the existence or nonexistence of familial clustering.
Methods:
The subjects were participants in the Basic Health Check Service 1999. We administered a questionnaire and obtained blood samples from 865 subjects (306 men, 559 women) who agreed to participate in our study.
Results:
Hyperhomocysteinemia was present in 52 men (17.0%) and 25 women (4.5%). Ten subjects who had hyperhomosysteinemia ha a family member who also had hyperhomocysteinemia. The odds ratio for hyperhomocysteinemia adjusted for age and sex was 4.77 (p < 0.01, 95% CI = 1.95-11.65).
Conclusion:
Hyperhomocysteinemia shows familial clustering. Men and elderly persons were more likely to have hyperhomocysteinemia.
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