Related Experiment Videos

Serum uric acid for risk stratification of patients with coronary artery disease

Yafim Brodov1, Pierre Chouraqui, Ilan Goldenberg

  • 1Heart Institute, Sheba Medical Center, Tel Hashomer, Israel. brodov_y@bezeqint.net

Cardiology
|September 25, 2009
PubMed

Insights

Elevated serum uric acid (SUA) in coronary artery disease (CAD) patients predicts cardiac events. This risk remains significant even after accounting for kidney function, highlighting SUA as an independent predictor.

Area of Science:

  • Cardiology
  • Nephrology
  • Metabolic Syndrome

Background:

  • Elevated serum uric acid (SUA) is linked to adverse cardiovascular outcomes in coronary artery disease (CAD).
  • Renal function significantly influences SUA levels.
  • The independent predictive value of SUA in CAD patients, considering renal function, requires further elucidation.

Purpose of the Study:

  • To evaluate the predictive capability of serum uric acid (SUA) levels for cardiovascular events in patients with coronary artery disease (CAD).
  • To determine if the association between SUA and cardiovascular outcomes persists after adjusting for renal function, specifically estimated glomerular filtration rate (eGFR).

Main Methods:

  • Analysis of 2,796 nondiabetic CAD patients from the Bezafibrate Infarction Prevention study.
  • Assessment of primary endpoint (PEP) risk, including myocardial infarction (MI) and sudden death, across SUA quintiles.
  • Statistical adjustments for multiple clinical variables and eGFR to ascertain the independent association of SUA with PEP risk.

Main Results:

  • A dose-response relationship was observed, with the highest SUA quintile showing the highest PEP risk (18.0%).
  • Elevated SUA remained a significant predictor of PEP risk (HR: 1.47) after comprehensive clinical adjustments.
  • This association persisted even after additional adjustment for eGFR (HR: 1.46), indicating independence from renal function.

Conclusions:

  • In nondiabetic patients with CAD, elevated serum uric acid (SUA) levels are independently associated with an increased risk of cardiac events.
  • Serum uric acid serves as a valuable prognostic marker for cardiovascular outcomes in CAD, irrespective of renal function.
Abstract

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...