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A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
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Published on: August 16, 2017

A transgenic mouse model for gene-nutrient interactions.

Jing X Kang1

  • 1Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass., USA. kang.jing@mgh.harvard.edu

Journal of Nutrigenetics and Nutrigenomics
|September 25, 2009
PubMed
Summary
This summary is machine-generated.

The novel fat-1 transgenic mouse model converts n-6 to n-3 fatty acids, enabling diet-independent studies of nutrient-gene interactions and their effects on gene expression.

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Area of Science:

  • Nutritional Science
  • Genetics
  • Molecular Biology

Background:

  • Dietary evaluation is complex due to nutrient interactions.
  • Confounding factors from diet limit studies on nutrient-gene interactions.
  • A controlled model is needed to isolate nutrient effects.

Purpose of the Study:

  • To introduce the fat-1 transgenic mouse model.
  • To highlight its ability to independently alter fatty acid profiles.
  • To demonstrate its utility in studying nutrient-gene interactions.

Main Methods:

  • Genetic engineering of mice with the Caenorhabditis elegans fat-1 gene.
  • The fat-1 gene enables endogenous conversion of n-6 to n-3 fatty acids.
  • This conversion is independent of dietary intake.

Main Results:

  • The fat-1 mouse model achieves increased n-3 fatty acids and a balanced n-6/n-3 ratio in tissues.
  • This fatty acid modulation occurs irrespective of the consumed diet.
  • Preliminary studies show significant effects on gene expression.

Conclusions:

  • The fat-1 mouse model offers a unique platform for studying nutrient-gene interactions.
  • It minimizes dietary confounding factors, allowing precise investigation of fatty acid metabolism.
  • This model is crucial for understanding how balanced fatty acid ratios influence biological processes.