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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
Dipyridodiazepinone derivatives; synthesis and anti HIV-1 activity
Nisachon Khunnawutmanotham1, Nitirat Chimnoi, Arunee Thitithanyanont
1Chulabhorn Research Institute, Vibhavadee-Rangsit Highway, Bangkok 10210, Thailand.
Beilstein Journal of Organic Chemistry
|September 25, 2009
Abstract:
Ten dipyridodiazepinone derivatives were synthesized and evaluated for their anti HIV-1 reverse transcriptase activity against wild-type and mutant type enzymes, K103N and Y181C. Two of them were found to be promising inhibitors for HIV-1 RT.
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