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Related Experiment Videos

Postural hypotension in chronically medicated schizophrenics.

H Silver1, H Kogan, D Zlotogorski

  • 1Flugelman (Mazra) Psychiatric Hospital, Doar-Na Ashrat, Israel.

The Journal of Clinical Psychiatry
|November 1, 1990
PubMed
Summary
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Chronic schizophrenic patients on antipsychotics exhibit lower resting blood pressure and significantly higher rates of postural hypotension compared to healthy individuals. This blood pressure issue was prevalent even with stable medication, suggesting a link to long-term antipsychotic use.

Area of Science:

  • Psychiatry
  • Pharmacology
  • Cardiovascular Medicine

Background:

  • Antipsychotic medications are standard treatments for chronic schizophrenia.
  • Potential side effects of antipsychotics on cardiovascular function require thorough investigation.
  • Postural hypotension, a drop in blood pressure upon standing, is a known concern with some medications.

Purpose of the Study:

  • To compare blood pressure regulation, specifically resting blood pressure and postural hypotension, in chronically medicated schizophrenic patients versus healthy controls.
  • To investigate the prevalence and characteristics of postural hypotension in patients receiving long-term antipsychotic treatment.

Main Methods:

  • Blood pressure measurements (resting and postural) were taken in 196 patients with chronic schizophrenia on stable antipsychotic treatment.

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  • A control group of unmedicated healthy individuals was used for comparison.
  • Prevalence of postural hypotension was assessed at 1 and 3 minutes after standing.

    • Main Results:

    • Schizophrenic patients had significantly lower resting blood pressure than controls.
    • A high prevalence of postural hypotension was observed in patients: 77% at 1 minute and 16.8% at 3 minutes post-standing.
    • Postural hypotension prevalence was largely independent of age, sex, and drug dose (except in young patients), and not predicted by alpha 1-receptor binding affinity.

    Conclusions:

    • Chronic antipsychotic treatment in schizophrenia is associated with persistent postural hypotension.
    • The findings highlight a significant cardiovascular side effect in this patient population.
    • Further research is needed to understand the clinical implications and management of this condition.