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Updated: Jun 20, 2026
09:20
An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
Published on: May 4, 2021
Adipokines: emerging therapeutic targets.
Katarina Kos1, John P H Wilding
1University Hospital Aintree, Diabetes and Endocrinology Research Unit, Longmoor Lane, Liverpool L9 7AL, UK. katarina.kos@pcmd.ac.uk
Current Opinion in Investigational Drugs (London, England : 2000)
|September 25, 2009
Summary
Adipose tissue secretes adipokines that influence organ communication and health. While some adipokines offer benefits, others pose risks, necessitating careful therapeutic strategies.
Area of Science:
- Endocrinology
- Physiology
- Immunology
Background:
- Adipose tissue influences physiology via secreted adipokines.
- Adipokines mediate inter-organ communication.
- The role of adipokines in various pathologies is not fully understood.
Purpose of the Study:
- To explore the complex roles of adipokines in human physiology and pathology.
- To highlight the need for further research into adipokine functions.
Main Methods:
- Review of existing literature on adipokines and their physiological effects.
- Analysis of the dual beneficial and harmful effects of specific adipokines, such as leptin.
Main Results:
- Adipokines play a significant role in inter-organ crosstalk.
- Adipokines can have both beneficial (e.g., weight regulation) and detrimental (e.g., immune suppression) effects.
- The pathophysiological significance of many adipokines requires further investigation.
Conclusions:
- Pharmacological targeting of adipokines requires a cautious approach due to potential adverse effects.
- Novel strategies may be needed to achieve organ-specific or action-specific targeting of adipokines.
- Further research is crucial to fully elucidate the complex roles of adipokines in health and disease.
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