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Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
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Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

Published on: September 10, 2018

Acute monocytic leukemia in pregnancy. Report of a case treated with 6-mercaptopurine in the first trimester

P RAVENNA, P J STEIN

    American Journal of Obstetrics and Gynecology
    |September 25, 2009
    PubMed

    6-Mercaptopurine given during pregnancy to a patient suffering from acute monocytic leukemia (histiocytic or Schilling's type) permitted the birth of a premature but otherwise normal infant. The drug was given from the sixth to the eighth week and from the twenty-eighth to the thirty-first week of pregnancy, in doses sufficient to cause two remissions and two episodes of hypoplastic anemia.

    Keywords:
    6-MERCAPTOPURINE/therapeutic useLEUKEMIA, MONOCYTIC, ACUTE/drug therapyPREGNANCY COMPLICATIONS, NEOPLASTIC/drug therapy

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