Related Experiment Video

Updated: Jun 20, 2026

Establishment of Central Cord Syndrome Model in C57BL/6J Mouse
06:36

Establishment of Central Cord Syndrome Model in C57BL/6J Mouse

Published on: September 8, 2023

Central spinal cord syndrome in hyper-extension injuries of the cervical spine

R W RAND, P H CRANDALL

    The Journal of Bone and Joint Surgery. American Volume
    |September 25, 2009
    PubMed

    Related Concept Videos

    Herniated Intervertebral Disc l: Introduction01:29

    Herniated Intervertebral Disc l: Introduction

    Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
    Secondary Spinal Cord Injury llI: Pathophysiology01:25

    Secondary Spinal Cord Injury llI: Pathophysiology

    Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
    Spinal Cord Injury ll: Pathophysiology01:14

    Spinal Cord Injury ll: Pathophysiology

    Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
    Spinal Cord: Gross Anatomy01:15

    Spinal Cord: Gross Anatomy

    The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...
    The Spinal Cord01:54

    The Spinal Cord

    The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
    Spinal Cord01:26

    Spinal Cord

    The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.