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Published on: February 7, 2019
Convenient large-scale synthesis of D-glucaro-1,4:6,3-dilactone
Troy C Gehret1, A Stephen Frobese, James S Zerbe
1Central Research & Development, E. I. DuPont de Nemours & Co., Experimental Station, Wilmington, Delaware 19880, USA.
Abstract:
Calcium D-glucarate was converted into D-glucaro-1,4:6,3-dilactone on 32-g, 1-kg, and 22-kg scale, using azeotropic distillation with methyl isobutyl ketone to drive the dehydration. The crystalline product was > or = 99.5% pure by GC and NMR, and overall yield was as high as 72%.
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