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Related Experiment Video

Updated: Feb 19, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
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Anetoderma in cutaneous marginal-zone B-cell lymphoma.

E Zattra1, B Pigozzi, M Bordignon

  • 1Department of Dermatology, University of Padua, Padua, Italy.

Clinical and Experimental Dermatology
|September 26, 2009
PubMed
Summary

A rare skin condition, anetoderma, was linked to cutaneous marginal-zone B-cell lymphoma in a patient presenting with chronic nodules and plaques. This finding suggests a potential role for lymphocytes in anetoderma pathogenesis.

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Area of Science:

  • Dermatology
  • Hematology
  • Oncology

Background:

  • Anetoderma is characterized by localized skin laxity due to dermal elastic fiber deficiency.
  • The exact pathogenesis of anetoderma remains largely unknown.
  • Cutaneous lymphomas can present with diverse dermatological manifestations.

Observation:

  • A 45-year-old male patient had a 25-year history of progressive deep nodules and plaques.
  • These lesions evolved into characteristic areas of anetoderma.
  • Histological examination revealed neoplastic cells with lymphoplasmacytoid morphology.

Findings:

  • Immunohistochemical analysis showed neoplastic cells positive for CD20, CD38, and CD138.
  • Monoclonal kappa light chain gene rearrangement confirmed plasma cell clonality.
  • A diagnosis of cutaneous marginal-zone B-cell lymphoma was established.

Implications:

  • This case suggests a potential association between cutaneous marginal-zone B-cell lymphoma and anetoderma.
  • The study proposes that cytokines or soluble factors from infiltrating lymphocytes may contribute to the development of anetoderma.
  • Further research is warranted to elucidate the link between lymphoproliferative disorders and anetoderma.