Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Infertility in Females

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...

Ovarian Cycle

Ovarian Cycle

The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...

Meiosis II

Meiosis II

Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each containing...

Restarting Stalled Replication Forks

Restarting Stalled Replication Forks

DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart, a...

Infertility in Males

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

Meiosis vs. Mitosis

Meiosis vs. Mitosis

Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Understanding regression analysis: what is inside the box?

Reproductive biomedicine online·2026

Same author

LH supplementation in ovarian stimulation: propensity score and generalized estimating equations analysis over 2000 embryos.

Frontiers in endocrinology·2026

Same author

Higher endometrial thickness prior frozen embryo transfer is associated with lower first-trimester placental growth factor.

European journal of obstetrics, gynecology, and reproductive biology·2026

Same author

An advanced SWOT analysis of elective vitrification: today's standard IVF procedure.

Reproductive biomedicine online·2026

Same author

'The more, the better' a decade later. Still true?

Human reproduction (Oxford, England)·2026

Same author

Intrapatient variability in the number of retrieved oocytes and ovarian response categories between consecutive in vitro fertilization cycles.

Fertility and sterility·2026

Search research articles

Related Experiment Video

Updated: Jun 20, 2026

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

How do you solve the problem of recurrent miscarriage?

Spyridon Tzioras¹, Nikolaos P Polyzos, Demetrios L Economides

¹Department of Obstetrics and Gynecology, Royal Free Hospital, London, UK. spyrostz@hotmail.com

Reproductive Biomedicine Online

|September 26, 2009

Summary

Recurrent miscarriage (RM) affects 1% of couples, causing distress. Evidence-based practice and dedicated clinics are crucial for effective, safe patient care and research.

More Related Videos

Platform for Quantitative Detection of Endometrial Immune Cells Based on Immunohistochemistry and Digital Image Analysis

Platform for Quantitative Detection of Endometrial Immune Cells Based on Immunohistochemistry and Digital Image Analysis

Published on: October 13, 2023

Measurement of Four Uterine NK Cell Subtypes Using Multiplexed Fluorescent Immunohistochemical Staining in Women with Repeated Implantation Failure

Measurement of Four Uterine NK Cell Subtypes Using Multiplexed Fluorescent Immunohistochemical Staining in Women with Repeated Implantation Failure

Published on: October 25, 2024

Related Experiment Videos

Last Updated: Jun 20, 2026

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

Platform for Quantitative Detection of Endometrial Immune Cells Based on Immunohistochemistry and Digital Image Analysis

Platform for Quantitative Detection of Endometrial Immune Cells Based on Immunohistochemistry and Digital Image Analysis

Published on: October 13, 2023

Measurement of Four Uterine NK Cell Subtypes Using Multiplexed Fluorescent Immunohistochemical Staining in Women with Repeated Implantation Failure

Measurement of Four Uterine NK Cell Subtypes Using Multiplexed Fluorescent Immunohistochemical Staining in Women with Repeated Implantation Failure

Published on: October 25, 2024

Area of Science:

Reproductive Medicine
Clinical Obstetrics
Genetics

Background:

Recurrent miscarriage (RM) involves two or more consecutive pregnancy losses, impacting 1% of couples.
Current investigations and treatments for RM are often controversial and lack robust evidence.
The emotional toll on patients and clinicians is significant, highlighting the need for specialized care.

Purpose of the Study:

To advocate for evidence-based practices in managing recurrent miscarriage.
To emphasize the importance of psychological support for women experiencing RM.
To highlight the necessity of dedicated RM clinics for specialized care and research.

Main Methods:

Review of current practices and literature regarding recurrent miscarriage.
Emphasis on the principles of evidence-based medicine.
Discussion of the role of psychological support and specialized clinics.

Main Results:

A significant proportion of women with RM experience anxiety or depression.
Unproven investigations and treatments for RM should be discontinued.
Dedicated RM clinics can prevent harmful treatments and facilitate research.

Conclusions:

Implementing evidence-based guidelines is essential for recurrent miscarriage management.
Psychological support is a critical component of care for women with RM.
Specialized recurrent miscarriage clinics improve patient outcomes and advance research.