Related Experiment Video
Updated: Jun 20, 2026

Targeted Knockdown of Genes in the Choroid Plexus
Published on: June 16, 2023
AhR and ARNT modulate ER signaling
Elin Swedenborg1, Ingemar Pongratz
1Department of Biosciences and Nutrition, Karolinska Institutet at Novum, S-141 57 Huddinge, Sweden.
Abstract:
The aryl hydrocarbon receptor (AhR), in complex with its binding partner ARNT, mediates the cellular response to xenobiotic compounds such as the environmental pollutant dioxin. In addition, the AhR has important regulatory roles in normal physiology. For instance, there is extensive data showing an intricate relationship between the AhR and estrogen receptor (ER) pathways. This review focuses on the regulatory roles of AhR and ARNT, beyond the response to xenobiotics. In particular, the effects of AhR agonists on the estrogen signaling pathways and the role of ARNT as a modulator of ER activity are discussed.
Related Concept Videos
Cell Signaling in Plants
Endocrine Signaling
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Calmodulin-dependent Signaling
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
Amplifying Signals via Enzymatic Cascade
Intracellular Signaling Cascades

