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Updated: Jun 20, 2026
06:01
Production of Extracellular Matrix Fibers via Sacrificial Hollow Fiber Membrane Cell Culture
Published on: February 2, 2019
Extracellular matrix biomaterials for soft tissue repair
Kevin G Cornwell1, Adam Landsman, Kenneth S James
1TEI Biosciences Inc., 7 Elkins Street, Boston, MA 02127, USA.
Clinics in Podiatric Medicine and Surgery
|September 26, 2009
Summary
Extracellular matrix (ECM) implants offer biological and physical benefits, with processing methods influencing their integration into the body. Different ECM devices can be resorbed, encapsulated, or regenerate new tissue (gTissue).
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Extracellular matrix (ECM) derived implants are increasingly utilized in regenerative medicine.
- Conventional biomaterial wisdom is challenged by the diverse biological and physical augmentation ECM implants provide.
- Post-implantation responses vary significantly based on ECM processing.
Purpose of the Study:
- To review clinically available ECM devices.
- To highlight the impact of tissue source and processing on ECM implant properties.
- To discuss host-implant interactions and surgical considerations for ECM devices.
Main Methods:
- Review of current clinical ECM devices.
- Analysis of tissue processing methodologies and their effect on ECM properties.
- Evaluation of host-implant interactions and surgical applications.
Main Results:
- ECM processing dictates host responses, including foreign body encapsulation, degradation/resorption, or tissue regeneration (gTissue).
- Tissue source and processing significantly influence ECM physicomechanical properties.
- Varied host-implant interactions are observed depending on the ECM device and its application.
Conclusions:
- ECM implant performance is highly dependent on tissue source and processing techniques.
- Understanding these factors is crucial for optimizing surgical applications and clinical outcomes.
- ECM technology offers diverse strategies for tissue augmentation and regeneration.
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01:29The Extracellular Matrix
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
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A...
A...
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