Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Production of Pharmaceuticals01:30

Production of Pharmaceuticals

Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under sterile, tightly...
Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Photoredox-Catalyzed Lysine C(sp<sup>3</sup>)-H Functionalization for Peptide Editing.

Journal of the American Chemical Society·2026
Same author

Small Molecule Catalyst for Peptide Synthesis.

Journal of the American Chemical Society·2025
Same author

From Concepts to Inhibitors: A Blueprint for Targeting Protein-Protein Interactions.

Chemical reviews·2025
Same author

Reengineering of a Proteomimetic Pan-Ras Inhibitor into a Ras Degrader.

Angewandte Chemie (International ed. in English)·2025
Same author

Probing Thrombosis Initiation with Lasso Peptide Variants as Inhibitors to the von Willebrand Protein-Collagen Interaction.

Chembiochem : a European journal of chemical biology·2025
Same author

C2230, a preferential use- and state-dependent CaV2.2 channel blocker, mitigates pain behaviors across multiple pain models.

The Journal of clinical investigation·2024
Same journal

DIVERSE System: De Novo Creation of Peptide Tags for Non-enzymatic Covalent Labeling by In Vitro Evolution for Protein Imaging Inside Living Cells.

Chemistry & biology·2015
Same journal

Differential Regulation of Specific Sphingolipids in Colon Cancer Cells during Staurosporine-Induced Apoptosis.

Chemistry & biology·2015
Same journal

Synthetic Peptides as cGMP-Independent Activators of cGMP-Dependent Protein Kinase Iα.

Chemistry & biology·2015
Same journal

Unraveling the B. pseudomallei Heptokinase WcbL: From Structure to Drug Discovery.

Chemistry & biology·2015
Same journal

Vitamin C as Cancer Destroyer, Investigating Sulfhydration, and the Variability in CFTR Interactome.

Chemistry & biology·2015
Same journal

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.

Chemistry & biology·2015
See all related articles

Related Experiment Video

Updated: Jun 20, 2026

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

Making strides in peptide-based therapeutics.

Danielle A Guarracino1, Paramjit S Arora

  • 1Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA.

Chemistry & Biology
|September 26, 2009
PubMed
Summary
This summary is machine-generated.

Scientists designed novel alpha/beta-peptides that effectively mimic a key alpha helix. These peptides show potent activity against human immunodeficiency virus (HIV) by blocking viral entry.

More Related Videos

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
11:09

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

Published on: August 1, 2018

Related Experiment Videos

Last Updated: Jun 20, 2026

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
11:09

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

Published on: August 1, 2018

Area of Science:

  • Biochemistry
  • Structural Biology
  • Virology

Background:

  • The entry of human immunodeficiency virus (HIV) into host cells is mediated by interactions involving viral envelope proteins, including the gp41 protein which forms an alpha-helical structure crucial for membrane fusion.
  • Mimicking or disrupting these essential viral structures presents a viable strategy for developing antiviral therapies.

Purpose of the Study:

  • To design and characterize novel alpha/beta-peptides capable of mimicking the functional alpha-helix of gp41.
  • To evaluate the antiviral activity of these designed peptides against HIV entry.

Main Methods:

  • Utilizing principles of peptide design and synthesis to create hybrid alpha/beta-peptides.
  • Employing biophysical techniques for structural characterization of the designed peptides.
  • Assessing the inhibitory activity of the peptides in HIV-1 viral entry assays.

Main Results:

  • Successful design and synthesis of alpha/beta-peptides that adopt a stable helical conformation.
  • Demonstration that these peptides effectively mimic the structure of the gp41-mediated fusion interface.
  • Significant potent activity observed in inhibiting HIV-1 viral entry in vitro.

Conclusions:

  • Alpha/beta-peptides can be rationally designed to mimic viral protein structures involved in host cell entry.
  • These findings offer a promising new class of antiviral agents targeting HIV fusion.
  • The study validates the potential of alpha/beta-peptides as therapeutic scaffolds for infectious diseases.