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[Antineoplastic effect of koumine in mice bearing H22 solid tumor]
Jing Cai1, Lin-sheng Lei, De-biao Chi
1College of Pharmacy, Southern Medical University, Guangzhou, China.
Objective:
To investigate the antitumor effects of koumine in mice bearing H22 solid tumor and its effect on the immune system of the mice.
Methods:
The changes in spleen and tumor weights and blood cell count were observed after koumine treatment in BALB/c athymic mice bearing H22 solid tumor, using normal saline solution and 5-Fu as the controls.
Results:
Koumine significantly inhibited the tumor growth in a dose-dependent manner. The spleen index and blood cell counts in koumine group showed no significant differences from those in the saline control group, but higher than those in 5-Fu group.
Conclusion:
Koumine can significantly inhibit the growth of H22 solid tumor without obvious inhibitory effect on the immune system in mice.
