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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Related Experiment Video

Updated: Jun 20, 2026

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)
08:30

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)

Published on: May 16, 2012

MicroRNAs and prostate cancer.

Valeria Coppola1, Ruggero De Maria, Désirée Bonci

  • 1Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore Sanità, viale Regina Elena 299, 00161 Rome, Italy. valeria.coppola@iss.it

Endocrine-Related Cancer
|September 26, 2009
PubMed
Summary

New diagnostic and therapeutic tools are needed for advanced prostate cancer. MicroRNAs show promise as diagnostic, prognostic, and therapeutic biomolecules for this disease.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer management requires improved tools for predicting severity and guiding treatment.
  • Advanced prostate cancer necessitates more effective therapeutic strategies.
  • MicroRNAs (miRNAs) are increasingly recognized for their roles in cancer.

Purpose of the Study:

  • To critically review the current knowledge on microRNA deregulation in prostate cancer.
  • To explore the potential of microRNAs as diagnostic, prognostic, and therapeutic biomarkers.
  • To identify current limitations and future directions in the field.

Main Methods:

  • Comprehensive literature review of studies on microRNA deregulation in prostate cancer.
  • Critical analysis of existing data on miRNA roles as oncogenes and tumor suppressors.

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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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miRNA Expression Analyses in Prostate Cancer Clinical Tissues

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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

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Last Updated: Jun 20, 2026

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)
08:30

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)

Published on: May 16, 2012

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

  • Synthesis of current findings and future perspectives.

    • Main Results:

    • MicroRNA deregulation is evident in prostate cancer, with miRNAs acting as oncogenes or tumor suppressors.
    • Evidence supports the potential use of specific microRNAs as diagnostic and prognostic biomarkers.
    • MicroRNAs offer potential as therapeutic targets or agents for prostate cancer treatment.

    Conclusions:

    • MicroRNAs represent a promising class of molecules for advancing prostate cancer diagnosis, prognosis, and therapy.
    • Further research is needed to overcome current limitations and fully realize the clinical potential of miRNAs.
    • Targeting microRNA pathways may lead to novel and more effective treatments for advanced prostate cancer.