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Updated: Jun 20, 2026

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

Quantum-dot-modified microbubbles with bi-mode imaging capabilities.

Hengte Ke¹, Zhanwen Xing, Bo Zhao

¹Nanobiotechnology Division, Bio-X Center, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin 150001, People's Republic of China.

|September 26, 2009

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Researchers developed a novel dual-mode imaging agent by combining microbubbles (MBs) with quantum dots (QDs). This new agent enables both ultrasound and fluorescent imaging, offering potential for advanced biomedical applications.

Area of Science:

Biomedical Engineering
Nanotechnology
Medical Imaging

Background:

Microbubbles (MBs) are widely used as contrast agents in ultrasound imaging.
Quantum dots (QDs) offer unique fluorescent properties for bioimaging.
Developing multi-modal imaging agents can enhance diagnostic capabilities.

Purpose of the Study:

To create a novel bi-modal ultrasound/fluorescent imaging agent.
To functionalize ST68 microbubbles with Cadmium Telluride (CdTe) quantum dots (QDs).
To evaluate the imaging properties and targeted delivery potential of the developed agent.

Main Methods:

Layer-by-layer deposition of poly(allylamine hydrochloride) (PAH) and CdTe QDs onto microbubbles.
Characterization using photoluminescence spectroscopy and confocal laser scanning microscopy.

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Imaging and Quantification of the Area of Fast-Moving Microbubbles Using a High-Speed Camera and Image Analysis

Imaging and Quantification of the Area of Fast-Moving Microbubbles Using a High-Speed Camera and Image Analysis

Published on: September 5, 2020

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Last Updated: Jun 20, 2026

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

Imaging and Quantification of the Area of Fast-Moving Microbubbles Using a High-Speed Camera and Image Analysis

Imaging and Quantification of the Area of Fast-Moving Microbubbles Using a High-Speed Camera and Image Analysis

Published on: September 5, 2020

Evaluation of size distribution, ultrasound contrast enhancement, and ultrasound-targeted microbubble destruction (UTMD).

Main Results:

Successful adsorption of CdTe QDs onto the microbubble surface was confirmed.
QD-modified MBs exhibited suitable size for clinical application and maintained ultrasound contrast.
UTMD experiments demonstrated the agent's capability for targeted QD delivery for fluorescent imaging.

Conclusions:

A novel dual-mode ultrasound/fluorescent imaging agent was successfully developed.
The QD-modified MBs retain ultrasound imaging capabilities and can serve as a targeted delivery system.
This dual-functional agent holds significant potential for diverse biological and medical applications.