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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Updated: Jun 20, 2026

Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats
09:31

Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats

Published on: March 30, 2018

Stem cell platforms for regenerative medicine.

Timothy J Nelson1, Atta Behfar, Satsuki Yamada

  • 1Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Clinical and Translational Science
|September 26, 2009
PubMed
Summary
This summary is machine-generated.

Regenerative medicine utilizes diverse stem cells for tissue repair, offering new hope for chronic diseases. Engineered stem cells and tailored therapies promise personalized cures for currently incurable conditions.

Keywords:
adultallogeneicautologousbioengineeredembryonicimmune responseperinatal

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Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells
04:23

Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells

Published on: March 31, 2021

Related Experiment Videos

Last Updated: Jun 20, 2026

Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats
09:31

Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats

Published on: March 30, 2018

Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells
04:23

Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells

Published on: March 31, 2021

Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Tissue Engineering

Background:

  • Aging populations face a rise in chronic degenerative diseases requiring novel tissue repair strategies.
  • Stem cells, including embryonic and adult progenitors, are crucial for innate healing and tissue reconstruction.
  • Nuclear reprogramming has expanded the potential of stem cell therapies.

Purpose of the Study:

  • To explore the role of diverse stem cell platforms in regenerative medicine.
  • To discuss strategies for translating stem cell therapies into clinical practice.
  • To highlight the potential for personalized stem cell biotherapeutics in treating incurable diseases.

Main Methods:

  • Review of natural stem cell sources (embryonic to adult progenitors).
  • Investigation of engineered stem cells via nuclear reprogramming.
  • Analysis of regenerative strategies: replacement, regeneration, and rejuvenation.

Main Results:

  • Identification of unique regenerative characteristics across various stem cell types.
  • Demonstration of expanded applicability through engineered stem cells.
  • Elucidation of distinct therapeutic approaches for diverse clinical needs.

Conclusions:

  • Stem cell platforms offer promising avenues for treating chronic degenerative diseases.
  • Personalized application of stem cell biologics, matched to patient-specific niches, is key for optimal long-term management.
  • Integration of discovery science and clinical translation is poised to revolutionize medicine with effective stem cell biotherapeutics.