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Updated: Jun 20, 2026
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Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
Published on: August 17, 2022
Optimal utilization of extended hepatic grafts
Sherilyn Gordon Burroughs1, Ronald W Busuttil
1Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095-7054, USA.
Surgery Today
|September 26, 2009
Summary
Expanded criteria donors (ECD) offer a solution to liver transplant shortages. Careful matching of ECD grafts can minimize recipient risk and optimize outcomes, addressing critical organ availability issues.
Area of Science:
- Organ transplantation
- Hepatology
- Surgical innovation
Background:
- End-stage liver disease necessitates orthotopic liver transplantation.
- Significant increase in patients awaiting liver transplants versus stagnant donor organ availability.
- Global organ shortage leads to increased wait-list mortality.
Purpose of the Study:
- To review the importance of extended criteria donor (ECD) factors in liver transplantation.
- To evaluate the impact of a graft matching strategy to mitigate recipient risk.
- To optimize the use of available donor organs to address transplant shortages.
Main Methods:
- Review of factors associated with extended criteria donor (ECD) grafts.
- Analysis of donor characteristics including advanced age, hypernatremia, prolonged warm ischemic time, pressor requirement, and donation after cardiac death.
- Evaluation of graft matching strategies to minimize recipient risk.
Main Results:
- Extended criteria donor (ECD) grafts present a viable option for increasing organ availability.
- Judicious use and careful matching of ECD grafts can lead to acceptable outcomes.
- Identifying and mitigating risks associated with ECD factors is crucial.
Conclusions:
- Donor pool expansion through strategies like utilizing ECD grafts is essential.
- A strategic matching approach is key to successfully incorporating ECDs into the transplant program.
- Optimizing graft utilization through careful selection and matching can improve liver transplant accessibility and outcomes.
