Related Experiment Videos
Coagulation factor abnormalities as possible thrombotic risk factors after Fontan operations
A H Cromme-Dijkhuis1, C M Henkens, C M Bijleveld
1Division of Pediatric Cardiology, University Hospital, Groningen, The Netherlands.
Lancet (London, England)
|November 3, 1990
Summary
Patients undergoing Fontan-type operations face a high risk of thromboembolism due to coagulation factor abnormalities, particularly protein C deficiency. This imbalance contributes to thrombotic events years after congenital heart defect correction.
Area of Science:
- Cardiology
- Hematology
- Pediatric Surgery
Background:
- Fontan-type operations are palliative procedures for complex congenital heart defects.
- Patients with corrected congenital heart defects may experience long-term complications, including thromboembolism.
Purpose of the Study:
- To investigate the prevalence of coagulation factor abnormalities in patients post-Fontan-type operation.
- To determine if these abnormalities correlate with the high incidence of thromboembolism.
Main Methods:
- Screening of 37 patients post-Fontan-type operation for coagulation factor abnormalities.
- Analysis of identified abnormalities, focusing on protein C, antithrombin III, and factors II and X.
Main Results:
- 3 out of 37 patients experienced severe thromboembolism.
- 24 out of 37 patients exhibited 63 coagulation factor abnormalities.
- Protein C deficiency was the most common abnormality, with significantly lower levels of antithrombin III, factors II, and X in affected patients.
Conclusions:
- Coagulation factor abnormalities, especially protein C deficiency, are prevalent in patients after Fontan-type operations.
- An imbalance between procoagulant and anticoagulant factors likely contributes to the elevated thrombotic risk in this population.