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Updated: Jun 20, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
Unintentional parathyroidectomy and hypoparathyroidism in secondary central compartment surgery for thyroid cancer
Michael P Ondik1, Johnathan McGinn, Francis Ruggiero
1Division of Otolaryngology - Head and Neck Surgery, Department of Surgery, Penn State Hershey Medical Center, University School of Medicine, 500 University Drive, MCH091, Hershey, PA 17033-0850, USA.
Background:
Unintentional parathyroidectomy is a complication of thyroid surgery. To our knowledge, no study has specifically examined the incidence of inadvertent parathyroidectomy exclusively in patients undergoing secondary central compartment surgery for recurrent or persistent thyroid cancer.
Methods:
The records of 40 patients who underwent 42 secondary central compartment surgeries for thyroid cancer were reviewed to determine the incidence of inadvertent parathyroidectomy.
Results:
Parathyroid tissue was present on permanent pathology in 31% of SCCSs. Unintentional parathyroidectomy did not have an effect on hypoparathyroidism. Concomitant lateral neck dissection did not have an effect on the incidence of hypoparathyroidism, but did have a statistically significant effect on inadvertent parathyroidectomy.
Conclusion:
Accidental resection of parathyroid tissue is relatively common in secondary central compartment surgery compared with primary thyroid surgery, but does not appear to correlate with postoperative hypoparathyroidism.
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