Psychosis following mycoplasma pneumonia
Related Experiment Video
Updated: Jun 20, 2026

Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae
Published on: February 24, 2023
Bonita Banerjee1, Kyle Petersen
1Naval Health Clinic Corpus Christi, 10651 E. Street, Corpus Christi, TX 78419, USA.
Abstract:
Extrapulmonary manifestations of Mycoplasma pneumoniae are well described, including a subset of central nervous system (CNS)-associated syndromes. In pediatric populations, frequencies of CNS sequelae occur in 0.1% to 7% of patients. Neurologic illness associated with M. pneumoniae, such as meningitis, encephalitis, polyradiculitis, Guillain-Barre, and stroke have been reported; however, the incidence of M. pneumoniae-associated organic brain syndrome is rare. We present the case of a 20-year-old midshipman with acute psychosis following resolution of M. pneumoniae pneumonia and review 6 other adult cases found in the literature. M. pneumoniae remains one of the most common causes of respiratory illnesses in the military recruit setting and therefore should always be suspected as an organic cause of mental status changes in young persons such as recruits, cadets, and midshipmen particularly with antecedent respiratory illnesses.
Insights
Mycoplasma pneumoniae can cause rare organic brain syndrome in adults, including acute psychosis. This respiratory illness is common in military settings and should be considered in young individuals with mental status changes.
Area of Science:
- Neurology
- Infectious Diseases
- Psychiatry
Background:
- Mycoplasma pneumoniae commonly causes respiratory infections.
- Extrapulmonary manifestations, including central nervous system (CNS) syndromes, are known but rare.
- Organic brain syndrome associated with M. pneumoniae is infrequently reported.
Observation:
- A case of a 20-year-old midshipman presenting with acute psychosis after M. pneumoniae pneumonia is described.
- A literature review identified 6 additional adult cases of M. pneumoniae-associated organic brain syndrome.
- The patient experienced acute psychosis following pneumonia resolution.
Findings:
- Mycoplasma pneumoniae can lead to rare but serious neurological complications.
- Organic brain syndrome, manifesting as acute psychosis, is a potential sequela.
- The incidence of M. pneumoniae-associated organic brain syndrome in adults is rare.
Implications:
- M. pneumoniae should be considered as an organic cause of altered mental status in young adults, especially military recruits.
- Clinicians should maintain a high index of suspicion for CNS complications in patients with M. pneumoniae infections.
- Early recognition and diagnosis are crucial for appropriate management of M. pneumoniae-induced neurological syndromes.
Related Concept Videos
Atypical Pneumonia
Pneumonia II: Pathophysiology
Pneumonia I: Introduction
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia III: Complications and Assessment
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...