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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Cytotoxic diterpenoids from Croton argyrophylloides
Hélcio S Santos1, Francisco W A Barros, Maria Rose Jane R Albuquerque
1Centro de Ciências Exatas e Tecnologia, Universidade Estadual Vale do Acaraú, 62040-370, Sobral, CE, Brazil.
Abstract:
Two new diterpenes, 1 and 2, together with the known ent-15-oxo-kaur-16-en-18-oic acid (3), were isolated from the bark of Croton argyrophylloides. The structural characterization of 1 and 2 was determined on the basis of spectroscopic data interpretation. The cytotoxicity of each compound was evaluated against HL-60 (leukemia), MDAMB-435 (melanoma), SF-295 (glioblastoma), and HCT-8 (colon carcinoma) human tumor cell lines and against human peripheral blood mononuclear cells. The hemolytic potential in mouse erythrocytes was also tested for 1-3.
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