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Collagenofibrotic glomerulopathy: three case reports in Brazil.
Renata D R Ferreira1, Fabiano B Custódio, Camila S O Guimarães
1Discipline of General Pathology, Biological Sciences Department, Triângulo Mineiro Federal University, Uberaba, Minas Gerais State, Brazil. rosanaasor@hotmail.com
Diagnostic Pathology
|September 29, 2009
Summary
Collagenofibrotic glomerulopathy (CG), a kidney disease, is now reported in South America, indicating it affects diverse populations globally. This finding expands the known geographical distribution of CG beyond Japan.
Area of Science:
- Nephrology
- Pathology
- Genetics
Background:
- Collagenofibrotic glomerulopathy (CG) is a rare kidney disease.
- Previously, CG was primarily reported in Japan, suggesting a potential geographical limitation.
Purpose of the Study:
- To report the first cases of collagenofibrotic glomerulopathy in South America.
- To highlight that CG is not limited to specific races or locations.
Main Methods:
- Case series describing three patients with common clinical factors: sex, age, non-nephrotic proteinuria, and microscopic hematuria.
- Immunofluorescence microscopy showed typically negative results for immunoglobulins and complement components.
- Picrosyrius staining revealed reddish material in the mesangium, which appeared greenish under polarized light, indicating collagen.
- Electron microscopy confirmed characteristic curved and disorganized collagen fibers.
Main Results:
- Identification of collagenofibrotic glomerulopathy in three patients from South America.
- Clinical presentation included proteinuria and hematuria with negative immunofluorescence findings.
- Distinctive collagen fiber morphology confirmed via electron microscopy.
Conclusions:
- These cases represent the first reported instances of CG in South America.
- Collagenofibrotic glomerulopathy is an idiopathic renal disease with a global distribution.
- CG should be considered in the differential diagnosis of proteinuria, particularly in unexplained cases.
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