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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: Jun 20, 2026

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

Published on: March 20, 2026

[Differential proteomics in glioblastoma].

Zhan-Kao Zhao¹, Zhong-Min Jiang, Xiao-Zhi Liu

¹Department of Pathology, Department of Neurosurgery, Affiliated Hospital of Medical College of Chinese People's Armed Police Force, Tianjin 300162, China.

Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology

|September 29, 2009

Summary

Researchers identified 10 unique proteins in Chinese glioblastoma cell lines, offering insights into tumor development and potential therapeutic targets. This proteomics study provides a foundation for future glioblastoma research.

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Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue

Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue

Published on: August 28, 2021

Area of Science:

Proteomics
Cancer Biology
Molecular Oncology

Context:

Glioblastoma is an aggressive brain tumor with complex molecular underpinnings.
Understanding differential protein expression is crucial for identifying therapeutic targets.
Previous studies have not fully characterized the proteomics of Chinese glioblastoma cell lines.

Purpose:

To establish differential proteomics profiles of Chinese glioblastoma cell lines.
To identify unique proteins associated with glioblastoma.
To provide a reference for future basic and translational research.

Summary:

This study analyzed protein expression in three Chinese glioblastoma cell lines (CHG-5, TJ899, TJ905) using two-dimensional electrophoresis.
Ten unique proteins were identified, involved in cytoskeleton formation, metabolism, migration, and stress/inflammatory responses.
Immunocytochemistry and immunohistochemistry confirmed the presence of these proteins in solid tumors, differentiating them from normal glia cells.

Impact:

Identified distinct proteomics profiles in glioblastoma cell lines compared to normal glia.
The identified proteins may play roles in glioblastoma pathogenesis and progression.
Provides a valuable proteomic dataset for advancing glioblastoma research and therapeutic strategies.