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In Vitro Fertilization

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

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Related Experiment Video

Updated: Jun 20, 2026

Minimally Invasive Embryo Transfer and Embryo Vitrification at the Optimal Embryo Stage in Rabbit Model

Minimally Invasive Embryo Transfer and Embryo Vitrification at the Optimal Embryo Stage in Rabbit Model

Published on: May 16, 2019

A frozen-thawed embryo transfer program improves the embryo utilization rate.

Feng Zhou¹, Xiao-na Lin, Xiao-mei Tong

¹Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China.

Chinese Medical Journal

|September 29, 2009

Summary

This summary is machine-generated.

Freezing all embryos for frozen-thawed embryo transfer (FET) significantly improves implantation and pregnancy rates in infertility treatment. This approach enhances overall embryo utilization compared to fresh embryo transfer.

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Area of Science:

Reproductive Endocrinology
In Vitro Fertilization
Embryology

Background:

Frozen-thawed embryo transfer (FET) is a key strategy in assisted reproductive technology.
FET aims to mitigate risks like ovarian hyperstimulation syndrome and boost cumulative pregnancy rates.
Evaluating FET program effectiveness is crucial for optimizing infertility treatment outcomes.

Purpose of the Study:

To assess the impact of an all-embryo freezing FET program on implantation and clinical pregnancy rates.
To determine if this FET strategy enhances overall embryo utilization in infertility treatment.
To compare outcomes between an all-freeze FET group and a fresh embryo transfer group.

Main Methods:

Retrospective analysis of 179 patients in an all-freeze FET group (C1) versus 1306 patients in a fresh embryo transfer group (T1).
Logistic regression modeling to analyze implantation and pregnancy rates based on maternal age, oocytes retrieved, and embryo quality.
Statistical adjustments for confounding factors including age and oocyte yield were performed.

Main Results:

The all-freeze FET group (C1) demonstrated significantly higher embryo implantation (43.6% vs 29.0%) and clinical pregnancy rates (63.1% vs 47.0%) compared to the fresh transfer group (T1).
These benefits were observed across different maternal age groups and oocyte retrieval numbers (especially ≥15 oocytes).
Higher implantation and pregnancy rates in the FET group were also noted when transferring two or three embryos.

Conclusions:

A strategy of freezing all embryos followed by FET significantly enhances embryo implantation and clinical pregnancy rates.
This comprehensive FET program leads to improved overall embryo utilization in infertility treatment.
The findings support the adoption of all-embryo freezing protocols for optimizing IVF success.