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Interrelationships of Factor VII activity and plasma leptin with insulin resistance in coronary heart disease

Rubina A Karatela1, Gurmukh S Sainani

  • 1Jaslok Hospital and Research Centre, Dr. G. Deshmukh Marg, Mumbai, India. rubina_k@msn.com

Atherosclerosis
|September 29, 2009
PubMed

Insights

In coronary heart disease (CHD) patients, elevated Factor VII activity (FVIIc) and leptin levels are independently linked to insulin resistance. This association was not found in individuals without CHD.

Area of Science:

  • Cardiovascular Science
  • Metabolic Syndrome Research
  • Hemostasis and Thrombosis

Background:

  • Factor VII activity (FVIIc) is a potential independent cardiovascular risk factor.
  • The relationship between FVII, leptin, and insulin resistance in coronary heart disease (CHD) remains unclear.

Purpose of the Study:

  • To investigate the independent associations of plasma FVII activity and leptin with insulin resistance in CHD patients.
  • To determine if these associations differ between CHD patients and non-CHD controls.

Main Methods:

  • A study of 130 subjects (65 CHD, 65 controls).
  • Measured plasma levels of FVIIc, leptin, insulin, glucose, fibrinogen, and lipids.
  • Assessed body mass index (BMI), waist circumference (WC), and blood pressure.

Main Results:

  • CHD subjects exhibited higher FVIIc, leptin, and insulin resistance than controls.
  • FVIIc and leptin levels were positively correlated with insulin resistance in CHD patients.
  • Multivariate analysis confirmed FVIIc and leptin independently associated with insulin resistance in CHD, irrespective of other factors.

Conclusions:

  • Elevated FVII and leptin levels are independently associated with insulin resistance in CHD patients.
  • These independent associations were not observed in the non-CHD control group.
Abstract

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