Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cerebral malaria in children.

R E Phillips1, T Solomon

  • 1Institute of Molecular Medicine, John Radcliffe Hospital, Oxford.

Lancet (London, England)
|December 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Paediatric meningitis in the conjugate vaccine era and a novel clinical decision model to predict bacterial aetiology.

The Journal of infection·2024
Same author

Corrigendum to "Global uncertainty in the diagnosis of neurological complications of SARS-CoV-2 infection by both neurologists and non-neurologists: An international inter-observer variability study" [Journal of the Neurological Sciences. 2023 Jun 15;449:120646].

Journal of the neurological sciences·2023
Same author

Global uncertainty in the diagnosis of neurological complications of SARS-CoV-2 infection by both neurologists and non-neurologists: An international inter-observer variability study.

Journal of the neurological sciences·2023
Same author

Understanding the policy dynamics of COVID-19 in the UK: Early findings from interviews with policy makers and health care professionals.

Social science & medicine (1982)·2020
Same author

Treatment of MOG antibody associated disorders: results of an international survey.

Journal of neurology·2020
Same author

Discovery of novel plasma biomarkers for future incident venous thromboembolism by untargeted synchronous precursor selection mass spectrometry proteomics.

Journal of thrombosis and haemostasis : JTH·2018
Same journal

Safety and efficacy of mRNA vaccines: a mechanistic and public health perspective.

Lancet (London, England)·2026
Same journal

The US Ebola response and the future of global health leadership.

Lancet (London, England)·2026
Same journal

Daniel Mason: a tale of change.

Lancet (London, England)·2026
Same journal

The 2026 Wakley-Wu Lien Teh Prize Essay: why medicine, and why stay?

Lancet (London, England)·2026
Same journal

Indonesia's health reform: from pandemic mandate to the six pillars of transformation.

Lancet (London, England)·2026
Same journal

LGBTQ+ Russians increasingly avoiding doctors.

Lancet (London, England)·2026
See all related articles

Cerebral malaria, a severe brain complication of malaria, has high mortality. New treatments are urgently needed as drug resistance to current therapies like quinine is a growing concern.

Area of Science:

  • Tropical medicine
  • Infectious diseases
  • Neurology

Background:

  • Cerebral malaria is a life-threatening encephalopathy with high mortality.
  • A key feature is the accumulation of Plasmodium falciparum-infected red blood cells in cerebral capillaries.
  • Molecular mechanisms of infected red blood cell adhesion are under investigation.

Purpose of the Study:

  • To review the current understanding of cerebral malaria pathophysiology.
  • To assess the clinical relevance of molecular adhesion studies.
  • To evaluate current and needed treatment strategies for cerebral malaria.

Main Methods:

  • Literature review of molecular adhesion studies.
  • Analysis of current treatment guidelines and drug resistance patterns.

Related Experiment Videos

  • Assessment of the pathophysiology of cerebral malaria.

    • Main Results:

    • Adhesion of infected red blood cells to endothelium is a potential trigger for cerebral malaria.
    • The clinical relevance of molecular adhesion studies remains uncertain.
    • Chloroquine resistance is widespread, and quinine resistance is emerging, necessitating alternative treatments.

    Conclusions:

    • Effective treatment options for cerebral malaria are limited due to widespread drug resistance.
    • Urgent development of alternative drugs is critical to combat rising resistance.
    • Further research is needed to bridge molecular findings with clinical application in cerebral malaria.