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Circadian Entrainment of Drosophila Melanogaster
Published on: June 3, 2020
Internal noise-driven circadian oscillator in Drosophila
1The Institute for Chemical Physics, Beijing Institute of Technology, Beijing, 100081, China. qsli@bit.edu.cn
Biophysical Chemistry
|September 29, 2009
Summary
Internal noise can sustain reliable circadian rhythms in the Drosophila model, even when the system would otherwise be stable. Optimal noise levels enhance oscillation coherence, demonstrating intrinsic coherence resonance.
Area of Science:
- * Computational biology
- * Systems biology
- * Biophysics
Background:
- * Circadian rhythms are endogenous biological processes regulating daily cycles.
- * Feedback mechanisms are essential for generating robust circadian oscillations.
- * The role of internal noise in maintaining circadian rhythms is not fully understood.
Purpose of the Study:
- * To investigate the effect of internal noise on a two-variable Drosophila circadian clock model.
- * To determine if internal noise can sustain oscillations in a previously stable system.
- * To analyze the phenomenon of intrinsic coherence resonance in circadian rhythms.
Main Methods:
- * Simulation of a two-variable Drosophila circadian clock model incorporating internal noise.
- * Analysis of system dynamics using phase plane analysis.
- * Evaluation of oscillation coherence and period in response to varying noise intensities.
Main Results:
- * Internal noise sustains reliable oscillations in parameter regimes that yield stable steady states in the deterministic system.
- * Noise-sustained oscillations exhibit a slight fluctuation in period around the deterministic value.
- * Oscillation coherence is maximized at an optimal internal noise intensity, demonstrating intrinsic coherence resonance.
- * In the oscillatory region, increasing internal noise suppresses coherence but minimally affects the oscillation period.
Conclusions:
- * Internal noise plays a crucial role in sustaining circadian oscillations in the Drosophila model.
- * The model exhibits intrinsic coherence resonance, where an optimal noise level enhances oscillation reliability.
- * The Drosophila circadian clock model demonstrates robustness to intrinsic noise, particularly concerning oscillation period.
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