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Contrast medium volume to estimated glomerular filtration rate ratio as a predictor of contrast-induced nephropathy

Tsuyoshi Nozue1, Ichiro Michishita, Taku Iwaki

  • 1Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, 132 Katsura-cho, Sakae-ku, Yokohama 247-8581, Japan. nozue2493@yahoo.co.jp

Journal of Cardiology
|September 29, 2009
PubMed

Insights

The contrast medium volume to estimated glomerular filtration rate (CMV/eGFR) ratio is a strong predictor of contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI). This ratio can help identify patients at risk for CIN, improving patient outcomes.

Area of Science:

  • Cardiology
  • Nephrology
  • Radiology

Background:

  • Contrast-induced nephropathy (CIN) is a significant complication following coronary angiography and percutaneous coronary intervention (PCI).
  • Identifying patients at risk for CIN is crucial for minimizing its incidence and associated adverse outcomes.

Purpose of the Study:

  • To investigate clinical factors associated with CIN development in patients undergoing elective PCI.
  • To identify a reliable predictor for CIN in this patient population.

Main Methods:

  • Retrospective analysis of 60 stable angina patients who underwent elective PCI.
  • Comparison of clinical factors, including baseline characteristics, procedural details, and contrast volume, between patients with and without CIN.
  • Statistical analysis, including stepwise regression, to identify independent predictors of CIN.

Main Results:

  • The incidence of CIN was 13%.
  • Patients who developed CIN had significantly lower estimated glomerular filtration rates (eGFR) and received higher volumes of contrast medium.
  • The contrast medium volume to eGFR ratio (CMV/eGFR) was significantly greater in the CIN group and identified as an independent predictor of CIN.
  • A CMV/eGFR ratio cutoff of >5.1 demonstrated 87.5% sensitivity and 74.5% specificity for detecting CIN.

Conclusions:

  • The CMV/eGFR ratio is a valuable and independent predictor of CIN following elective PCI.
  • This ratio can aid in risk stratification and inform preventative strategies for CIN.
Abstract

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