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Related Concept Videos

Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
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Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Related Experiment Video

Updated: Jun 20, 2026

Small Bowel Transplantation In Mice
36:30

Small Bowel Transplantation In Mice

Published on: August 20, 2007

Intestinal transplantation for motility disorders.

Alastair J W Millar1, Girish Gupte, Khalid Sharif

  • 1University of Cape Town and Red Cross Children's Hospital, Cape Town, South Africa. alastair.millar@uct.ac.za

Seminars in Pediatric Surgery
|September 29, 2009
PubMed
Summary

Intestinal transplantation (ITx) is a viable therapy for intestinal failure (IF). Careful patient selection and graft management can lead to successful ITx outcomes for patients with intestinal motility disorders.

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Last Updated: Jun 20, 2026

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Area of Science:

  • Gastroenterology and Hepatology
  • Transplantation Surgery
  • Abdominal Medicine

Background:

  • Intestinal transplantation (ITx) is an established therapy for intestinal failure (IF).
  • Motility disorders account for up to 25% of IF cases, presenting unique challenges.
  • Pathologies include nerve, smooth muscle, or idiopathic (chronic intestinal pseudo-obstruction) abnormalities.

Purpose of the Study:

  • To review intestinal transplantation for intestinal failure due to motility disorders.
  • To highlight potential pitfalls in case selection and management.
  • To discuss outcomes and the Birmingham, UK ITx unit's experience.

Main Methods:

  • Review of existing literature on ITx for motility disorders.
  • Analysis of patient selection criteria and post-transplant management strategies.
  • Brief review of outcomes from a specific ITx unit.

Main Results:

  • Outcomes for ITx in dysmotility patients were historically guarded.
  • Appropriate graft selection and consideration of residual bowel function are crucial.
  • Successful ITx is achievable with careful management, comparable to other IF indications.

Conclusions:

  • Intestinal transplantation is a viable option for intestinal failure caused by motility disorders.
  • Meticulous patient selection and graft management are key to successful outcomes.
  • Further research and data from experienced centers can refine treatment protocols.