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Updated: Jun 20, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Midline brain abnormalities in established bipolar affective disorder.

Tsutomu Takahashi¹, Gin S Malhi, Stephen J Wood

¹Department of Psychiatry, University of Melbourne and Melbourne Health, Melbourne Neuropsychiatry Centre, Victoria, Australia. tsutomu@med.u-toyama.ac.jp

Journal of Affective Disorders

|September 29, 2009

Summary

Bipolar disorder patients show differences in midline brain structures. Specifically, they have a shorter adhesio interthalamica (AI) and larger third ventricles, suggesting these abnormalities are linked to the disorder's neurobiology.

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Area of Science:

Neuroimaging
Psychiatry
Neuroanatomy

Background:

Cortico-limbic region alterations are noted in bipolar disorder.
Midline brain abnormalities and their link to cortico-limbic connectivity in bipolar disorder require further investigation.

Purpose of the Study:

To investigate midline brain structures in bipolar disorder using magnetic resonance imaging.
To compare the size of the adhesio interthalamica (AI) and cavum septi pellucidi (CSP), and third ventricular volume between bipolar I disorder patients and controls.

Main Methods:

Magnetic resonance imaging (MRI) was employed.
26 patients with bipolar I disorder and 24 matched controls were included.
Measurements included adhesio interthalamica (AI) length, cavum septi pellucidi (CSP) presence/size, and third ventricular volume.

Main Results:

No significant differences in cavum septi pellucidi (CSP) length or prevalence were found between groups.
Bipolar disorder patients exhibited a significantly shorter adhesio interthalamica (AI) compared to controls.
Third ventricular volume was significantly larger in patients with bipolar disorder.

Conclusions:

The findings suggest that the adhesio interthalamica (AI) and associated brain regions play a role in the neurobiology of bipolar disorder.
Further research is needed, as a comprehensive analysis of medication effects was limited by incomplete data.