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Updated: Jun 20, 2026

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
Published on: February 16, 2022
Hydrogen sulfide induces nitric oxide release from nitrite.
1Dipartimento di Chimica Organica A. Mangini, Università di Bologna, I-40136 Bologna, Italy. loris.grossi@unibo.it
Hydrogen sulfide acts as a cofactor for nitric oxide (NO) derivatives, enhancing NO release. This finding highlights the crucial interplay between these gasotransmitters in physiological processes.
Area of Science:
- Biochemistry
- Physiology
- Neuroscience
Background:
- Hydrogen sulfide (H₂S) is recognized as a gasotransmitter in cardiovascular and central nervous systems.
- The physiological actions of H₂S appear linked to the presence of nitric oxide (NO) and its derivatives.
Purpose of the Study:
- To provide chemical evidence for the role of H₂S as a cofactor in NO-derivative-induced nitric oxide release.
Main Methods:
- Chemical analysis to investigate the interaction between H₂S and NO-derivatives.
- Experimental studies to measure NO release.
Main Results:
- Demonstrated that H₂S acts as a cofactor for NO-derivatives.
- Showcased the ability of H₂S and NO-derivatives to induce nitric oxide release.
Conclusions:
- H₂S plays a significant role as a cofactor, modulating nitric oxide release.
- The interaction between H₂S and NO-derivatives is critical for physiological signaling.
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