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Updated: Jun 20, 2026

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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and antitumor activities of 3-modified 2-methoxyestradiol analogs
Lita S Suwandi1, Gregory E Agoston, Jamshed H Shah
1EntreMed, Inc., 9640 Medical Center Drive, Rockville, MD 20850, USA.
Bioorganic & Medicinal Chemistry Letters
|September 29, 2009
Abstract:
The syntheses of 2-methoxyestradiol analogs with modifications at the 3-position are described. The analogs were assessed for their antiproliferative, antiangiogenic, and estrogenic activities. Several lead substituents were identified with similar or improved antitumor activities and reduced metabolic liability compared to 2-methoxyestradiol.
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