Related Experiment Video
Updated: Jun 20, 2026
10:10
Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research
Published on: November 2, 2018
Mouse models for ATR deficiency.
1Human DNA Damage Response Disorders Group, Genome Damage & Stability Centre, University of Sussex, Falmer, Brighton, East Sussex BN1 9RQ, UK. m.o-driscoll@sussex.ac.uk
DNA Repair
|September 29, 2009
Summary
Ataxia-telangiectasia mutated (ATM) and ATR kinases manage DNA damage. New mouse models reveal ATR
Area of Science:
- Molecular Biology
- Genetics
- Cellular Biology
Background:
- ATM and ATR proteins are key regulators of DNA damage response pathways.
- These pathways are crucial for maintaining genomic stability.
- Distinct roles for ATM and ATR in cellular viability are suggested by knockout models.
Purpose of the Study:
- To overview and contrast sophisticated mouse models for studying ATR.
- To highlight advances in understanding ATR-dependent DNA damage response.
- To explore the impact of ATR defects on development, homeostasis, aging, and cancer.
Main Methods:
- Review of recent publications on conditional ATR-knockdown mouse models.
- Analysis of mouse models mimicking human ATR-Seckel syndrome mutations.
- Comparative analysis of different mouse models to understand ATR function.
Main Results:
- Conditional ATR-knockdown models offer insights into ATR's essential role.
- ATR-Seckel syndrome models illuminate the consequences of specific ATR mutations.
- These models reveal ATR's critical involvement in development and disease.
Conclusions:
- Sophisticated mouse models have significantly advanced the understanding of ATR's function.
- ATR's role extends beyond DNA repair to development, aging, and cancer.
- Further research using these models will elucidate ATR-dependent pathways.
