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Mutational analysis of Drosophila basigin function in the visual system.

Michelle Munro1, Yazan Akkam, Kathryn D Curtin

  • 1Department of Biological Sciences, 601 SCEN, Fulbright College of Arts and Sciences, University of Arkansas, Fayetteville, AR 72701, USA.

Gene
|September 29, 2009
PubMed
Summary

Drosophila basigin, a cell-surface glycoprotein, is crucial for photoreceptor structure and neuron-glia interactions in the fly visual system. Conserved domains are essential for its function, while the intracellular tail appears less critical.

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Area of Science:

  • Developmental Biology
  • Neuroscience
  • Molecular Biology

Background:

  • Drosophila basigin is an immunoglobulin superfamily cell-surface glycoprotein.
  • It plays a role in photoreceptor cell structure and neuron-glia interactions in the fly visual system.
  • Mammalian orthologs include EMMPRIN/CD147/basigin, neuroplastin, and embigin.

Purpose of the Study:

  • To identify the functional domains of Drosophila basigin required for photoreceptor cell structure and neuron-glia interactions.
  • To investigate the role of conserved residues within the basigin protein.

Main Methods:

  • Created mutant Drosophila basigin transgenes with alterations in conserved residues.
  • Introduced these transgenes into the fly genome.
  • Assessed the ability of mutant transgenes to rescue basigin-related defects in photoreceptor structure and neuron-glia interactions.

Main Results:

  • Mutations affecting the transmembrane domain and extracellular domains impaired basigin function.
  • The short intracellular tail did not appear essential for rescuing photoreceptor structure or neuron-glia interactions.
  • Transgenic mouse basigin could functionally replace Drosophila basigin, indicating conserved function.

Conclusions:

  • The transmembrane and extracellular domains of basigin are critical for its function in the Drosophila visual system.
  • The intracellular tail of basigin may not be essential for these specific visual system functions.
  • Basigin function in the visual system is conserved between Drosophila and mouse.