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Related Concept Videos

Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
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Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
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Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
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Translational Regulation

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Updated: Jun 20, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates

Published on: February 27, 2016

Sirtuin regulation in calorie restriction.

Xiaolei Qiu1, Katharine V Brown, Yehu Moran

  • 1Department of Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720, USA.

Biochimica Et Biophysica Acta
|September 29, 2009
PubMed
Summary
This summary is machine-generated.

Calorie restriction extends lifespan and prevents disease. Mammalian SIR2 homologs are key to understanding how this diet

Related Experiment Videos

Last Updated: Jun 20, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates

Published on: February 27, 2016

Area of Science:

  • Genetics and molecular biology
  • Aging research
  • Metabolic regulation

Background:

  • Calorie restriction (CR) is known to extend lifespan and prevent age-related diseases.
  • The molecular mechanisms underlying CR's benefits are being actively investigated.
  • The SIR2 gene family has emerged as a critical player in the CR response.

Purpose of the Study:

  • To summarize recent findings on the role of mammalian SIR2 homologs in the calorie restriction response.
  • To elucidate the coordinated regulation of CR by SIR2 family members.
  • To provide an overview of the molecular pathways involved.

Main Methods:

  • Review of recent genetic and molecular studies.
  • Analysis of data from model organisms.
  • Focus on mammalian SIR2 homologs.

Main Results:

  • Mammalian SIR2 homologs play a coordinated role in mediating the effects of calorie restriction.
  • These genes are involved in regulating cellular responses to nutrient availability.
  • Understanding their function is crucial for deciphering CR's health benefits.

Conclusions:

  • Mammalian SIR2 homologs are essential regulators of the calorie restriction response.
  • Further research into these genes will illuminate pathways for healthspan extension.
  • Targeting SIR2 homologs may offer therapeutic strategies for age-related diseases.