Related Experiment Video
Updated: Jun 20, 2026

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye
Published on: September 5, 2011
Hereditary thrombophilia and recurrence of ischemic placental disease
Eric Verspyck1, Jeanne-Yvonne Borg, Horace Roman
1Department of Obstetrics and Gynecology, Rouen University Hospital, France. eric.verspyck@chu-rouen.fr
Objective:
We sought to evaluate whether testing for hereditary thrombophilia alone or in combination with second-trimester uterine artery Doppler (UAD) is useful in predicting recurrent complications in patients with previous preeclampsia, placental abruption, or stillbirth.
Study Design:
Between 2001 and 2005, 110 consecutive women were included in the study and received 100 mg of aspirin daily. Adjustment was made for several maternal confounding factors using a logistic regression model.
Results:
After multivariable logistic regression analyses, only abnormal UAD assessment was significantly associated with recurrent complications (odds ratio, 11.2; 95% confidence interval, 3.8-32.6) Combining the results of UAD and the presence of laboratory markers of thrombophilia failed to improve the accuracy of UAD to predict recurrent complications.
Conclusion:
Hereditary thrombophilia testing is not useful in predicting recurrent complications in subsequent pregnancy.
Related Concept Videos
Disorders of Hemostasis
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Venous Thrombosis I: Introduction
Pulmonary Embolism I: Introduction
Pulmonary Embolism I: Introduction
Ischemic Stroke l: Introduction