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Updated: Jun 20, 2026

A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters
07:47

A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters

Published on: April 20, 2015

Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions

Karl Kunzelmann1, Patthara Kongsuphol, Fadi Aldehni

  • 1Institut für Physiologie, Universität Regensburg, Universitätsstrasse 31, D-93053 Regensburg, Germany. karl.kunzelmann@vkl.uni-regensburg.de

Cell Calcium
|September 29, 2009
PubMed
Summary

Two protein families, bestrophins and TMEM16 proteins, now reliably replicate calcium-activated chloride currents. TMEM16A (anoctamin 1) is crucial for epithelial function and a potential cystic fibrosis therapy target.

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