Related Experiment Video

Updated: Jun 20, 2026

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

RAGE, glomerulosclerosis and proteinuria: roles in podocytes and endothelial cells

Vivette D'Agati1, Shi Fang Yan, Ravichandran Ramasamy

  • 1Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

Trends in Endocrinology and Metabolism: TEM
|September 29, 2009
PubMed

Insights

The Receptor for Advanced Glycation Endproducts (RAGE) plays a key role in kidney disease. Blocking RAGE offers protection against nephropathy in various models, highlighting its therapeutic potential.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Immunology

Background:

  • Receptor for Advanced Glycation Endproducts (RAGE) is expressed in glomerular podocytes and endothelial cells.
  • RAGE levels increase during kidney disease, suggesting a role in pathogenesis.
  • Genetic variations in RAGE are associated with kidney disease states in humans.

Purpose of the Study:

  • To review the evidence linking RAGE to the development of nephropathy.
  • To summarize findings from both animal models and human studies.

Main Methods:

  • Review of existing literature on RAGE in kidney disease.
  • Analysis of studies involving RAGE antagonism or genetic deletion in disease models.
  • Examination of human genetic association studies.

Main Results:

  • Pharmacological inhibition or genetic deletion of RAGE significantly protects against podocyte damage, albuminuria, and glomerulosclerosis in experimental models.
  • Increased RAGE expression is observed in diseased kidneys.
  • Genetic polymorphisms of RAGE and levels of soluble RAGE correlate with kidney disease severity in humans.

Conclusions:

  • RAGE is implicated in the pathogenesis of various forms of nephropathy.
  • Targeting RAGE presents a potential therapeutic strategy for kidney diseases.

More Related Videos

Generation of Patient-Derived Podocytes from Skin Biopsies08:52

Generation of Patient-Derived Podocytes from Skin Biopsies

Published on: May 26, 2023

Assessment of Kidney Function in Mouse Models of Glomerular Disease09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Glomerular Filtration01:15

Glomerular Filtration

The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...