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Updated: Jun 20, 2026
09:57
System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
Antituberculosis activity of the molecular libraries screening center network library
Joseph A Maddry1, Subramaniam Ananthan, Robert C Goldman
1Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35205, USA. maddry@southernresearch.org
Tuberculosis (Edinburgh, Scotland)
|September 29, 2009
Summary
Researchers screened over 200,000 compounds to find new drug candidates against tuberculosis (TB). This screening identified novel chemical structures for developing future antitubercular agents to combat drug-resistant TB.
Area of Science:
- Medicinal Chemistry
- Drug Discovery
- Microbiology
Background:
- Tuberculosis (TB) requires new treatments due to drug resistance.
- Novel antitubercular agents targeting new pathways are urgently needed.
Purpose of the Study:
- Identify novel chemical scaffolds for antitubercular drug discovery.
- Screen a large library of small molecules against Mycobacterium tuberculosis.
Main Methods:
- High-throughput screening of 215,110 compounds.
- Utilized Mycobacterium tuberculosis strain H37Rv.
- Medicinal chemistry survey of screening results.
Main Results:
- Identified a variety of new, active scaffolds.
- Screening campaign provided initial hits for further research.
Conclusions:
- The screening identified promising starting points for new antitubercular agents.
- This approach can stimulate further research into novel TB drug discovery.
