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Surgical Treatment of an Endolymphatic Sac Tumor
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Repeat stereotactic radiosurgery for acoustic neuromas.

Hideyuki Kano1, Douglas Kondziolka, Ajay Niranjan

  • 1Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.

International Journal of Radiation Oncology, Biology, Physics
|September 29, 2009
PubMed
Summary
This summary is machine-generated.

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Repeat stereotactic radiosurgery (SRS) for acoustic neuromas is safe and effective, achieving tumor control in all patients. This treatment option shows promise for managing persistent tumor growth after initial management.

Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Oncology

Background:

  • Acoustic neuromas, benign tumors of the vestibulocochlear nerve, can recur or progress after initial treatment.
  • Stereotactic radiosurgery (SRS) is a primary treatment modality for acoustic neuromas.
  • Evaluating repeat SRS is crucial for managing persistent tumor growth.

Purpose of the Study:

  • To assess the efficacy and safety of repeat stereotactic radiosurgery (SRS) for acoustic neuromas.
  • To evaluate tumor control, clinical outcomes, and adverse radiation effects after re-irradiation.
  • To determine the role of repeat SRS in patients with progressing tumors post-initial management.

Main Methods:

  • Retrospective review of 6 patients who underwent repeat SRS for acoustic neuromas over 21 years.

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  • Analysis of tumor progression, patient demographics, SRS parameters (volume, dose, interval), and follow-up data.
  • Inclusion criteria: imaging evidence of tumor progression despite initial SRS.

    • Main Results:

    • All 6 patients achieved tumor control or regression after repeat SRS.
    • Median follow-up was 29 months post-second SRS.
    • No symptomatic adverse radiation effects or new neurological deficits were observed.

    Conclusions:

    • Repeat SRS is a safe and effective treatment for acoustic neuromas with persistent enlargement.
    • This approach offers a viable option for managing tumor progression after initial SRS.
    • Further studies with larger cohorts are warranted to confirm these findings.