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Updated: Jun 20, 2026
07:51
A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Published on: June 18, 2018
Modafinil does not serve as a reinforcer in cocaine abusers
Suzanne K Vosburg1, Carl L Hart, Margaret Haney
1College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, United States.
Drug and Alcohol Dependence
|September 29, 2009
Summary
Modafinil did not show reinforcing effects in cocaine abusers during a randomized controlled trial. This study suggests modafinil lacks abuse liability among individuals with a history of cocaine use.
Area of Science:
- Psychopharmacology
- Addiction Medicine
Background:
- Cocaine abuse remains a significant public health concern.
- Understanding potential therapeutic agents for substance use disorders is crucial.
Purpose of the Study:
- To assess the reinforcing and subjective effects of modafinil in individuals with a history of cocaine abuse.
- To determine if modafinil exhibits abuse liability in this population.
Main Methods:
- Double-blind, randomized, outpatient study design.
- Twelve participants with cocaine abuse history.
- Modafinil (200, 400, 600 mg) versus placebo administration in a choice paradigm.
Main Results:
- No significant difference in modafinil versus placebo administration.
- Subjective effects ratings were not dose-dependently altered by modafinil.
- Modafinil did not demonstrate reinforcing properties.
Conclusions:
- Modafinil does not appear to have abuse liability in cocaine abusers.
- Findings do not support modafinil as a substance with abuse potential in this demographic.
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