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Related Concept Videos

Somatosensory, Motor, and Association Cortex01:23

Somatosensory, Motor, and Association Cortex

The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at the...
Association Areas of the Cortex01:21

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Somatosensation01:33

Somatosensation

The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Cerebral Hemispheres01:05

Cerebral Hemispheres

The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...

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Related Experiment Video

Updated: Jun 20, 2026

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation
16:23

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Published on: May 23, 2017

Retrosplenial cortex connectivity in schizophrenia.

Robyn L Bluhm1, Jodi Miller, Ruth A Lanius

  • 1Department of Philosophy and Religious Studies, Old Dominion University, BAL9013, Norfolk, VA 23529, USA.

Psychiatry Research
|September 29, 2009
PubMed
Summary
This summary is machine-generated.

Resting-state functional connectivity in the brain

Related Experiment Videos

Last Updated: Jun 20, 2026

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation
16:23

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Published on: May 23, 2017

Area of Science:

  • Neuroscience
  • Psychiatry
  • Brain Imaging

Background:

  • Schizophrenia is associated with altered resting-state functional connectivity.
  • Previous research identified abnormalities in the default network in schizophrenia patients.
  • The retrosplenial cortex's role in schizophrenia connectivity remains underexplored.

Purpose of the Study:

  • To investigate alterations in retrosplenial cortex connectivity in schizophrenia patients.
  • To examine connectivity with default network regions and memory-associated areas.
  • To correlate connectivity patterns with positive symptom severity.

Main Methods:

  • Resting-state functional magnetic resonance imaging (fMRI) was used.
  • Connectivity of the retrosplenial cortex was analyzed in 17 schizophrenia patients and 17 healthy controls.
  • Correlation analyses were performed between brain regions and symptom severity.

Main Results:

  • Schizophrenia patients showed lower retrosplenial cortex correlations with temporal lobe and default network regions.
  • Negative correlation observed between retrosplenial cortex and medial prefrontal cortex in patients.
  • Increased connectivity between retrosplenial cortex and hallucination-associated areas (e.g., left superior temporal gyrus) correlated with positive symptoms.

Conclusions:

  • Spontaneous activity and connectivity of the retrosplenial cortex are altered in schizophrenia.
  • These alterations may underlie deficits in self-oriented processing.
  • Findings highlight the retrosplenial cortex as a potential target for understanding schizophrenia pathophysiology.