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Updated: Jun 20, 2026

An Assay for Measuring the Effects of Ethanol on the Locomotion Speed of Caenorhabditis elegans
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Published on: April 9, 2015

Comparative genomics of ethanolamine utilization.

Olga Tsoy1, Dmitry Ravcheev, Arcady Mushegian

  • 1Department of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia.

Journal of Bacteriology
|September 29, 2009
PubMed
Summary
This summary is machine-generated.

This study reveals the evolutionary path of ethanolamine utilization enzymes (EutBC) in bacteria, uncovering gene fusions and horizontal transfers. It also links bacterial food poisoning to metabolosome structures rather than specific utilization genes.

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Area of Science:

  • Microbial biochemistry and evolution
  • Bacterial metabolism and pathogenesis

Background:

  • Ethanolamine serves as a carbon and nitrogen source for diverse bacteria.
  • The ethanolamine-ammonia lyase (EutBC) enzyme is crucial for ethanolamine breakdown.
  • Gaps exist in understanding EutBC structure, mechanism, evolution, and regulation.

Purpose of the Study:

  • To computationally analyze EutBC structure, evolution, and regulatory links.
  • To investigate the evolutionary origins of ethanolamine utilization pathways.
  • To evaluate associations between food poisoning and diol utilization pathways.

Main Methods:

  • Computational analysis of EutBC sequences, structures, genome contexts, and phylogenies.
  • Identification of conserved DNA motifs for regulatory analysis.
  • Data-mining to assess links between food poisoning and metabolic pathways.

Main Results:

  • EutBC evolved through domain fusion and horizontal gene transfer across bacterial phyla.
  • A conserved DNA motif suggests coupled biosynthesis of EutBC apoenzyme and cofactor.
  • Bacterial food poisoning is more strongly linked to metabolosome structure than EutBC genes.

Conclusions:

  • The study elucidates the evolutionary history and regulatory mechanisms of ethanolamine utilization.
  • Findings provide insights into bacterial adaptation and the molecular basis of foodborne illness.
  • Metabolosome organization, not just specific utilization genes, may be key to pathogenesis.