Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 20, 2026

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde
07:04

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Published on: November 11, 2022

Adding chemical cross-links to a physical hydrogel.

Gaio Paradossi1, Ivana Finelli, Barbara Cerroni

  • 1Dipartimento di Scienze e Tecnologie Chimiche, Università di Roma Tor Vergata and CNR - SOFT, Italy. paradossi@stc.uniroma2.it

Molecules (Basel, Switzerland)
|September 29, 2009
PubMed
Summary

Synergistic hydrogels made from xanthan and konjac glucomannan can be stabilized by chemical cross-links. This cross-linking improves swelling and viscoelastic properties without affecting cell viability.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Size-Dependent Nonlinear Acoustic Responses and Stable Cavitation of Polymeric Microbubbles.

ACS biomaterials science & engineering·2025
Same author

Microbubble Shell Stiffness Engineering Enhances Ultrasound Imaging, Drug Delivery, and Sonoporation.

Advanced materials (Deerfield Beach, Fla.)·2025
Same author

Thermoresponsive Copolymer Microgels Synthesized via Single-Step Precipitation Polymerization: Random or Block Structure?

Small (Weinheim an der Bergstrasse, Germany)·2025
Same author

Perfluorobutane Nanodroplets for the Selective Sensing and Range Verification of Carbon-Ion Radiotherapy: In Vitro Evaluation on Cells.

ACS omega·2025
Same author

Intra-Arterial Super-Selective Delivery of Yttrium-90 for the Treatment of Recurrent Glioblastoma: In Silico Proof of Concept with Feasibility and Safety Analysis.

Pharmaceutics·2025
Same author

Toward a Theranostic Approach for the Brain Tumor Toxicity Profile of Polymer-Shelled Microbubbles.

ACS omega·2025

Area of Science:

  • Food science and biopharmaceuticals
  • Polymer science and hydrogel engineering

Background:

  • Synergistic hydrogels formed by polysaccharide mixtures, like xanthan and konjac glucomannan, are common in food and biopharma.
  • The gel's structure is stabilized by macromolecular complexes in solution, held together by non-covalent interactions.
  • These non-covalent bonds lead to melting of the complex and hydrogel structure in solution.

Purpose of the Study:

  • To investigate the effect of chemical cross-linking on the properties of synergistic xanthan-konjac glucomannan hydrogels.
  • To determine if chemical cross-linking can overcome the thermal instability of these hydrogels.
  • To assess the biocompatibility of chemically cross-linked hydrogels using fibroblast viability.

Main Methods:

  • Formation of synergistic hydrogels using xanthan and konjac glucomannan.

More Related Videos

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Cellular Encapsulation in 3D Hydrogels for Tissue Engineering
09:37

Cellular Encapsulation in 3D Hydrogels for Tissue Engineering

Published on: October 26, 2009

Related Experiment Videos

Last Updated: Jun 20, 2026

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde
07:04

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Published on: November 11, 2022

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Cellular Encapsulation in 3D Hydrogels for Tissue Engineering
09:37

Cellular Encapsulation in 3D Hydrogels for Tissue Engineering

Published on: October 26, 2009

  • Introduction of chemical cross-links using epichlorohydrin.
  • Analysis of hydrogel swelling behavior and viscoelastic properties.
  • Evaluation of NIH 3T3 fibroblast viability with the cross-linked hydrogel.

    • Main Results:

    • Chemical cross-linking eliminated the thermal melting behavior observed in non-cross-linked synergistic hydrogels.
    • Cross-linking significantly altered the swelling characteristics and viscoelastic properties of the hydrogel.
    • Epichlorohydrin, used as a cross-linker, did not negatively impact the viability of NIH 3T3 fibroblasts.

    Conclusions:

    • Chemical cross-linking provides a method to stabilize synergistic polysaccharide hydrogels, enhancing their functional properties.
    • The modified hydrogels exhibit improved thermal stability and tunable swelling and viscoelasticity.
    • The cross-linked hydrogels demonstrate good biocompatibility, suitable for potential biopharmaceutical applications.