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Updated: Jun 20, 2026

Investigating Migraine-Like Behavior Using Light Aversion in Mice
Published on: August 11, 2021
CGRP receptor antagonists: A new frontier of anti-migraine medications
Blanca Marquez de Prado1, Andrew F Russo
1Department of Physiology and Biophysics, 51 Newton Road, University of Iowa, Iowa City, IA 52242, USA.
Abstract:
Migraine is a chronic pain condition that affects 12% of the population. Currently, the most effective treatments are the triptans, but they are limited in their efficacy and have potentially deleterious cardiovascular complications. Based on basic science studies over the past decade, a new generation of anti-migraine drugs is now being developed. At the forefront of these studies is a new calcitonin gene-related peptide (CGRP) receptor antagonist that is as effective as triptans in the acute treatment of migraines, without the cardiovascular effects. This review will address the likely mechanisms and therapeutic potential of CGRP receptor antagonists.
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