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Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

HIGH DIMENSIONAL VARIABLE SELECTION.

Larry Wasserman1, Kathryn Roeder

  • 1Department of Statistics, Carnegie Mellon University, Pittsburgh, E-mail: larry@stat.cmu.edu , roeder@stat.cmu.edu.

Annals of Statistics
|September 29, 2009
PubMed
Summary
This summary is machine-generated.

This study investigates statistical guarantees for variable selection in high-dimensional models using multi-stage regression. The proposed screening and cleaning method offers consistent variable selection under specific conditions.

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Last Updated: Jun 20, 2026

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

Area of Science:

  • Statistics
  • Machine Learning
  • Econometrics

Background:

  • High-dimensional models present challenges for traditional statistical inference.
  • Variable selection is crucial for model interpretability and performance in these settings.
  • Existing methods may lack robust statistical guarantees.

Purpose of the Study:

  • To provide statistical guarantees for variable selection in high-dimensional models.
  • To evaluate the error rates and power of multi-stage regression methods.
  • To introduce a novel screening and cleaning approach for variable selection.

Main Methods:

  • A three-stage regression approach involving model screening, cross-validation, and hypothesis testing.
  • Exploration of three screening methods: LASSO, marginal regression, and forward stepwise regression.
  • Analysis of statistical properties like error rates and power.

Main Results:

  • The proposed multi-stage method demonstrates consistent variable selection under certain theoretical conditions.
  • Evaluation of the performance trade-offs between different screening techniques.
  • Insights into the reliability of variable selection in high-dimensional contexts.

Conclusions:

  • The developed multi-stage regression framework offers a principled way to achieve reliable variable selection.
  • The findings contribute to understanding the statistical guarantees achievable in high-dimensional data analysis.
  • This approach provides a valuable tool for researchers working with complex, high-dimensional datasets.